Diagnostic Utility of TTF-1 and P40 Immunohistochemical Markers for Subtyping of Non-Small Cell Lung Carcinoma
نویسندگان
چکیده
Background : Lung cancer is the leading cause of cancer-related mortality over worldwide. Although pathological diagnosis lung carcinoma limited as only small specimen available for diagnosis, availability targeted therapies has created a need precise subtyping non-small cell carcinoma. Several recent studies have demonstrated that use immunohistochemical markers can be helpful in differentiating squamous from adenocarcinoma not on surgically resected but also biopsy samples. Material and Methods: A cross-sectional study one year duration including 50 cases carcinomas guided biopsies were first reported Haematoxylin Eosin sections later subjected IHC using relevant TTF-1 p40. Results: In our with p40 aided 35 (92.1%) this diagnostic accuracy was found to statistically significant p value <0.001. On statistical analysis, showed 100% sensitivity 85.7% specificity differentiation whereas adenocarcinoma. Out cases, after IHC, 29 (58%) diagnosed carcinoma, 18 (36%) adenocarcinoma, 3 (6%) Conclusion: The minimalist based model samples effective correctly subtype most contribute sparing material molecular testing. Keywords: Non-small immunohistochemistry,
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ژورنال
عنوان ژورنال: Journal of medical sciences and health
سال: 2023
ISSN: ['2394-9481', '2394-949X']
DOI: https://doi.org/10.46347/jmsh.v9i1.22.393